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Shisu has presumably blue eyes and choppy blonde hair (similar to Casca's after the course of the Eclipse).
She was said to have gone insane after having a miscarriage. However, she had a very kind heart, which is evident by her willingness to raise Guts as if he were her own son.
Golden Age Arc
Shisu was Guts' adoptive mother and, possibly, Gambino's lover. She first encountered the recently born Guts who was underneath a withered tree of hanged bodies, covered in blood and mire. She took him in as her own to console her recent miscarriage. Although Gambino allowed her to do as she wished, he and his mercenary comrades regarded Guts as a bad omen.
When Guts turned three, Shisu was dying from the plague. Her final moments were holding onto Guts' right hand and calling out his name before she died. Despite his crude remarks toward her, Gambino had deep affection for Shisu; her death fueled his anger towards Guts, who he blamed for the death of Shisu.